Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.



Hemocompatibility Investigation and Improvement of Near-Infrared persistent luminescence nanoparticle ZnGa2O4:Cr3+ by Surface PEGylation

Abstract

Although near-infrared persistent luminescence nanoparticles are widely used in optical imaging of tumors and grafted cells, there is no report on the behavior of chromium-doped zinc gallate nanoparticles (ZnGa2O4:Cr3+, ZGC) in contact with blood. In this work, monodisperse ZGC with a size of about 10 nm usually used in bioimaging was synthesized by hydrothermal method. We have evaluated the effect of ZGC on blood in terms of hemolysis, erythrocyte morphology, erythrocyte aggregation, coagulation, thrombosis and complement system activation. We improved ZGC blood compatibility by functionalizing them with hydrophilic polyethylene glycol (PEG) polymers. Experimental results demonstrate that the pristine ZGC at a concentration of 0.5 mg mL-1 induce hemolysis, erythrocyte morphology changes and delayed clotting, whereas no significant difference is observed with PEGylated ZGC (ZGC-PEG). However, neither ZGC nor ZGC-PEG caused thrombosis and inflammatory complement activation, which provides a basic research for in vivo imaging.

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Feb 2019, accepted on 07 May 2019 and first published on 09 May 2019


Article type: Paper
DOI: 10.1039/C9TB00378A
J. Mater. Chem. B, 2019, Accepted Manuscript

  •   Request permissions

    Hemocompatibility Investigation and Improvement of Near-Infrared persistent luminescence nanoparticle ZnGa2O4:Cr3+ by Surface PEGylation

    Y. Jiang, Y. Li, C. Richard, D. Scherman and Y. Liu, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C9TB00378A

Search articles by author

Spotlight

Advertisements