Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 7, 2019
Previous Article Next Article

Peptide-mediated cationic micelles drug-delivery system applied on a VEGFR3-overexpressed tumor

Author affiliations

Abstract

Copolymers as a kind of drug delivery carrier always lack targeting efficiency. So a peptide conjugated to a drug delivery system has attracted much attention for tumor-targeted nanomedicine. Thus, we here report a conjugation compound consisting of a copolymer (PEG-b-PLL) and a peptide (Cys-Ile-Gln-Pro-Phe-Tyr-Pro, CP7). For receptor-mediated endocytosis by this peptide, the CP7-PEG-b-PLL conjugation significantly enhanced the chemotherapeutic efficacy as a potent nanocarrier compared with free DOX. The CP7-PEG-b-PLL exhibited excellent pharmacokinetic behavior via a radioactive iodine-131 (I) tracing method. With this, the CP7-PEG-b-PLL/DOX system showed better tumor growth inhibition when studied on A549 cell lines and subcutaneous tumor models, but with less toxicity than free DOX. All these results suggest that the CP7-modified drug cationic micelles could represent a novel platform for successful drug delivery toward VEGFR3-overexpressed tumors.

Graphical abstract: Peptide-mediated cationic micelles drug-delivery system applied on a VEGFR3-overexpressed tumor

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Aug 2018, accepted on 31 Dec 2018 and first published on 07 Jan 2019


Article type: Paper
DOI: 10.1039/C8TB02255K
Citation: J. Mater. Chem. B, 2019,7, 1076-1086

  •   Request permissions

    Peptide-mediated cationic micelles drug-delivery system applied on a VEGFR3-overexpressed tumor

    Q. Y. Wang, H. M. Li, Z. P. Dong, B. X. Li, M. Huo, T. Lu and Y. Wang, J. Mater. Chem. B, 2019, 7, 1076
    DOI: 10.1039/C8TB02255K

Search articles by author

Spotlight

Advertisements