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Peptide-mediated Cationic Micelles Drug Delivery System Applied on VEGFR3-overexpressed Tumor

Abstract

Copolymer as a kind of drug delivery carrier is always lack of targeting efficiency.So peptide conjugated to drug delivery system has attracted much attention for tumor-targeted nanomedicine. Thus we here reported a conjugation compound consisting of copolymer (PEG-b-PLL) and a peptide (Cys-Ile-Gln-Pro-Phe-Tyr-Pro, CP7). For the receptor-mediated endocytosis by this peptide, the CP7-PEG-b-PLL conjugation significantly enhanced the chemotherapeutic efficacy as a potent nanocarrier compared with free DOX. The CP7-PEG-b-PLL exhibited excellent pharmacokinetic behavior via radioactive iodine-131 (I) tracing method. With this, CP7-PEG-b-PLL/DOX system showed better tumor growth inhibition when studied on A549 cell lines and its subcutaneous tumor models, but with less toxicity than free DOX. All these results suggest that the CP7 modified drug cationic micelles can be a novel platform for the successful drug delivery towards VEGFR3-overexpressed tumor.

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Publication details

The article was received on 27 Aug 2018, accepted on 31 Dec 2018 and first published on 07 Jan 2019


Article type: Paper
DOI: 10.1039/C8TB02255K
Citation: J. Mater. Chem. B, 2019, Accepted Manuscript
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    Peptide-mediated Cationic Micelles Drug Delivery System Applied on VEGFR3-overexpressed Tumor

    Q. Wang, H. Li, Z. Dong, B. Li, M. Huo, T. Lu and Y. Wang, J. Mater. Chem. B, 2019, Accepted Manuscript , DOI: 10.1039/C8TB02255K

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