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Issue 44, 2019
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Glassy dynamics in models of confluent tissue with mitosis and apoptosis

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Abstract

Recent work on particle-based models of tissues has suggested that any finite rate of cell division and cell death is sufficient to fluidize an epithelial tissue. At the same time, experimental evidence has indicated the existence of glassy dynamics in some epithelial layers despite continued cell cycling. To address this discrepancy, we quantify the role of cell birth and death on glassy states in confluent tissues using simulations of an active vertex model that includes cell motility, cell division, and cell death. Our simulation data is consistent with a simple ansatz in which the rate of cell-life cycling and the rate of relaxation of the tissue in the absence of cell cycling contribute independently and additively to the overall rate of cell motion. Specifically, we find that a glass-like regime with caging behavior indicated by subdiffusive cell displacements can be achieved in systems with sufficiently low rates of cell cycling.

Graphical abstract: Glassy dynamics in models of confluent tissue with mitosis and apoptosis

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Article information


Submitted
05 May 2019
Accepted
27 Sep 2019
First published
01 Nov 2019

Soft Matter, 2019,15, 9133-9149
Article type
Paper
Author version available

Glassy dynamics in models of confluent tissue with mitosis and apoptosis

M. Czajkowski, D. M. Sussman, M. C. Marchetti and M. L. Manning, Soft Matter, 2019, 15, 9133
DOI: 10.1039/C9SM00916G

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