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Issue 32, 2019
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A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A

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Abstract

The photoprotection and isolation of marinomycin A using sporopollenin exine capsules (SpECs) derived from the spores of the plant Lycopodium clavatum is described. The marinomycins have a particularly short half-life in natural light, which severely impacts their potential biological utility given that they display potent antibiotic and anticancer activity. The SpEC encapsulation of the marinomycin A dramatically increases the half-life of the polyene macrodiolide to the direct exposure to UV radiation by several orders of magnitude, thereby making this a potentially useful strategy for other light sensitive bioactive agents. In addition, we report that the SpECs can also be used to selectively extract culture broths that contain the marinomycins, which provides a significantly higher recovery than with conventional XAD resins and provides concomitant photoprotection.

Graphical abstract: A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A

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Publication details

The article was received on 21 Mar 2019, accepted on 20 May 2019 and first published on 21 May 2019


Article type: Edge Article
DOI: 10.1039/C9SC01375J
Chem. Sci., 2019,10, 7549-7553
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A

    C. S. Bailey, J. S. Zarins-Tutt, M. Agbo, H. Gao, A. Diego-Taboada, M. Gan, R. B. Hamed, E. R. Abraham, G. Mackenzie, P. A. Evans and R. J. M. Goss, Chem. Sci., 2019, 10, 7549
    DOI: 10.1039/C9SC01375J

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      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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      [Original citation] - Published by The Royal Society of Chemistry.

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