Issue 18, 2019, Issue in Progress

Synthesis of 5-aminolevulinic acid with nontoxic regents and renewable methyl levulinate

Abstract

Synthesis of 5-aminolevulinic acid (5-ALA) was presented with novel bromination of biobased methyl levulinate (ML), followed by ammoniation and hydrolysis. Copper bromide (CuBr2) was employed as the bromination reagent with higher selectivity and activity instead of the conventional liquid bromine (Br2). 5-ALA was obtained in a high yield (64%) and purity (>95%) by optimum design, which is of great potential in industrialization.

Graphical abstract: Synthesis of 5-aminolevulinic acid with nontoxic regents and renewable methyl levulinate

Supplementary files

Article information

Article type
Paper
Submitted
28 Feb 2019
Accepted
20 Mar 2019
First published
01 Apr 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 10091-10093

Synthesis of 5-aminolevulinic acid with nontoxic regents and renewable methyl levulinate

Y. Zai, Y. Feng, X. Zeng, X. Tang, Y. Sun and L. Lin, RSC Adv., 2019, 9, 10091 DOI: 10.1039/C9RA01517E

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