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Issue 17, 2019
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Preactivation-based, iterative one-pot synthesis of anticoagulant pentasaccharide fondaparinux sodium

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Abstract

A preactivation-based, one-pot glycosylation method with exclusive stereoselectivity was accomplished for the rapid synthesis of fondaparinux. Two convergent routes for assembling three glucosamine building blocks and two uronic acid donors were developed, and these routes greatly simplified the preparation procedures and improved the synthetic efficiency. Both disaccharide acceptors were obtained efficiently by glycosylation. This strategy offers another possibility for the rapid synthesis of fondaparinux.

Graphical abstract: Preactivation-based, iterative one-pot synthesis of anticoagulant pentasaccharide fondaparinux sodium

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Publication details

The article was received on 04 Apr 2019, accepted on 10 Jul 2019 and first published on 12 Jul 2019


Article type: Research Article
DOI: 10.1039/C9QO00480G
Org. Chem. Front., 2019,6, 3116-3120

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    Preactivation-based, iterative one-pot synthesis of anticoagulant pentasaccharide fondaparinux sodium

    H. Jin, Q. Chen, Y. Zhang, K. Hao, G. Zhang and W. Zhao, Org. Chem. Front., 2019, 6, 3116
    DOI: 10.1039/C9QO00480G

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