Diastereoselective access to 2-aminoindanones via the rhodium(ii)-catalyzed tandem reaction involving O–H insertion and Michael addition

Abstract

A rhodium(II)-catalyzed tandem reaction involving the O–H insertion of N-sulfonyl 1,2,3-triazoles with H₂O and Michael addition has been developed for the construction of 2-amino-1-indanones by the formation of one new CO bond and one new C–C bond. The notable features of the strategy include acceptable to good yields, high diastereoselectivities, and mild conditions. It provides a good choice for the construction of libraries of highly functionalized indanone compounds.