[Ag(bpy)(PPhtBu2)(OCF3)]: a stable nucleophilic reagent for chemoselective and stereospecific trifluoromethoxylation of secondary alkyl nosylates

Abstract

The development of a thermally stable and light-insensitive nucleophilic trifluoromethoxylative reagent [Ag(bpy)(PPh^tBu₂)(OCF₃)] 2, which was synthesized in high yields via a three-step one-pot process from easily available trifluoromethyl triflate (TFMT) and AgF at room temperature, is described. The high reactivity of reagent 2 was demonstrated by its high yielding chemoselective and stereospecific S_N2-type trifluoromethoxylation with secondary alkyl nosylates.