Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 2, 2019
Previous Article Next Article

Pd(TFA)2-catalyzed direct arylation of quinoxalinones with arenes

Author affiliations


The direct C-3 arylation of quinoxalin-2-ones with arenes is achieved by a Pd(TFA)2-catalyzed cross-dehydrogenative coupling (CDC) reaction. A wide array of functionalities, including highly sensitive allyl- and benzyl group substituted quinoxalin-2(H)-ones, are readily assembled with arenes containing electron-donating and electron-withdrawing groups in this CDC reaction. Highly regioselective products are produced in good yields with stronger electron-donating groups than toluene and densely substituted arenes as coupling partners. This protocol represents an efficient technique to access various 3-arylbenzo[g]quinoxalinones and 2-aryl-4-methylpyrido[3,4-b]pyrazin-3(4H)-ones under mild conditions.

Graphical abstract: Pd(TFA)2-catalyzed direct arylation of quinoxalinones with arenes

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Nov 2018, accepted on 11 Dec 2018 and first published on 12 Dec 2018

Article type: Research Article
DOI: 10.1039/C8QO01250D
Citation: Org. Chem. Front., 2019,6, 231-235

  •   Request permissions

    Pd(TFA)2-catalyzed direct arylation of quinoxalinones with arenes

    S. Paul, H. D. Khanal, C. D. Clinton, S. H. Kim and Y. R. Lee, Org. Chem. Front., 2019, 6, 231
    DOI: 10.1039/C8QO01250D

Search articles by author