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Issue 2, 2019
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Pd(TFA)2-catalyzed direct arylation of quinoxalinones with arenes

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Abstract

The direct C-3 arylation of quinoxalin-2-ones with arenes is achieved by a Pd(TFA)2-catalyzed cross-dehydrogenative coupling (CDC) reaction. A wide array of functionalities, including highly sensitive allyl- and benzyl group substituted quinoxalin-2(H)-ones, are readily assembled with arenes containing electron-donating and electron-withdrawing groups in this CDC reaction. Highly regioselective products are produced in good yields with stronger electron-donating groups than toluene and densely substituted arenes as coupling partners. This protocol represents an efficient technique to access various 3-arylbenzo[g]quinoxalinones and 2-aryl-4-methylpyrido[3,4-b]pyrazin-3(4H)-ones under mild conditions.

Graphical abstract: Pd(TFA)2-catalyzed direct arylation of quinoxalinones with arenes

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Publication details

The article was received on 16 Nov 2018, accepted on 11 Dec 2018 and first published on 12 Dec 2018


Article type: Research Article
DOI: 10.1039/C8QO01250D
Citation: Org. Chem. Front., 2019,6, 231-235

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    Pd(TFA)2-catalyzed direct arylation of quinoxalinones with arenes

    S. Paul, H. D. Khanal, C. D. Clinton, S. H. Kim and Y. R. Lee, Org. Chem. Front., 2019, 6, 231
    DOI: 10.1039/C8QO01250D

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