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Issue 5, 2019
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Iodine-promoted one pot reaction of pyridin-2-amine with arylmethyl ketone and selenosulfonate: synthesis of 3-(alkylselanyl)-2-arylimidazo[1,2-a]pyridine under transition-metal free conditions

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Abstract

A new efficient approach for the I2 promoted selenium functionalization of in situ generated imidazoheterocycles from 2-bromoacetophenone and 2-aminopyridine utilizing aliphatic selenosulfonate as the selenium source under transition metal-free conditions is developed. The reaction features are good yields, being easy to perform, and applicability to versatile imidazoheterocycles via C–N bond and C–Se bond formation in one pot.

Graphical abstract: Iodine-promoted one pot reaction of pyridin-2-amine with arylmethyl ketone and selenosulfonate: synthesis of 3-(alkylselanyl)-2-arylimidazo[1,2-a]pyridine under transition-metal free conditions

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Publication details

The article was received on 15 Nov 2018, accepted on 03 Jan 2019 and first published on 04 Jan 2019


Article type: Research Article
DOI: 10.1039/C8QO01245H
Citation: Org. Chem. Front., 2019,6, 654-659

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    Iodine-promoted one pot reaction of pyridin-2-amine with arylmethyl ketone and selenosulfonate: synthesis of 3-(alkylselanyl)-2-arylimidazo[1,2-a]pyridine under transition-metal free conditions

    N. Jiang, Y. Fang, Y. Fang, S. Wang and S. Ji, Org. Chem. Front., 2019, 6, 654
    DOI: 10.1039/C8QO01245H

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