A radical-chain reaction of isocyanides with selenosulfonates and water: facile synthesis of selenocarbamates under metal-free conditions

Abstract

A facile synthesis of secondary selenocarbamates through metal-free multicomponent reactions of isocyanides, selenosulfonates and water is reported here. The reaction is easy to handle and proceeds smoothly under mild conditions. The desired products are isolated in good yields with broad tolerance of functional groups. Detailed investigation of the mechanism is conducted and a radical-chain reaction model is also proposed.