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Transition-metal free C3-amidation of quinoxalin-2(1H)-ones using Selectfluor as a mild oxidant

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Abstract

A practical and efficient synthetic route to construct a variety of 3-amidated quinoxalin-2(1H)-ones was developed via transition-metal free direct oxidative amidation of quinoxalin-2(1H)-ones with amidates using Selectfluor reagent as a mild oxidant. This protocol features mild reaction conditions, operational simplicity, broad substrate scope, and good to excellent yields.

Graphical abstract: Transition-metal free C3-amidation of quinoxalin-2(1H)-ones using Selectfluor as a mild oxidant

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Publication details

The article was received on 07 Oct 2019, accepted on 19 Nov 2019 and first published on 19 Nov 2019


Article type: Paper
DOI: 10.1039/C9OB02157D
Org. Biomol. Chem., 2019, Advance Article

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    Transition-metal free C3-amidation of quinoxalin-2(1H)-ones using Selectfluor as a mild oxidant

    J. Yuan, J. Zhu, B. Li, L. Yang, P. Mao, S. Zhang, Y. Li and L. Qu, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB02157D

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