Jump to main content
Jump to site search


Ethyl-for-methyl substitution enhances the subtype specificity of mecamylamine analogues

Author affiliations

Abstract

The synthesis of novel mecamylamine analogues is described in which one, two or three of the methyl groups of mecamylamine have been systematically replaced with ethyl groups. Assessment of the compounds highlights that simple ethyl for methyl changes changes to the parent structure can dramatically enhance activity and selectivity towards either the α4β2 (at the expense of α3β4) or the α3β4 (at the expense of α4β2) nicotinic acetylcholine receptor sub-type as compared to the parent compound.

Graphical abstract: Ethyl-for-methyl substitution enhances the subtype specificity of mecamylamine analogues

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Sep 2019, accepted on 01 Nov 2019 and first published on 06 Nov 2019


Article type: Paper
DOI: 10.1039/C9OB01993F
Org. Biomol. Chem., 2019, Advance Article

  •   Request permissions

    Ethyl-for-methyl substitution enhances the subtype specificity of mecamylamine analogues

    D. Mangan, N. McNabola, E. H. Clark, I. Bermudez, S. Wonnacott and J. M. Southern, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB01993F

Search articles by author

Spotlight

Advertisements