Organocatalytic enantioselective conjugate addition of pyrazolin-5-ones to arylomethylidene malonates†
Abstract
An efficient asymmetric organocatalytic conjugate addition reaction of pyrazolin-5-ones with arylomethylidene malonates has been successfully developed by employing bifunctional Cinchona derived thiourea organocatalysts. The protocol provides straightforward access to pyrazole substituted scaffolds in good yields with high stereocontrol.
- This article is part of the themed collections: Synthetic methodology in OBC and Catalysis & biocatalysis in OBC
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