Issue 43, 2019
From the journal:

Organic & Biomolecular Chemistry

Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis†

Collette S. Guy, ORCID logo ab   Kathryn Murray, ORCID logo b   Matthew I. Gibson ORCID logo *bc  and  Elizabeth Fullam ORCID logo *a  

* Corresponding authors

a School of Life Sciences, University of Warwick, UK
E-mail: e.fullam@warwick.ac.uk

b Department of Chemistry, University of Warwick, UK
E-mail: m.i.gibson@warwick.ac.uk

c Warwick Medical School, University of Warwick, UK

Abstract

Dimeric benzoboroxoles that are covalently linked by a short scaffold enhance selective anti-tubercular activity. These multimeric benzoboroxole compounds are capable of engaging the specific extracellular Mycobacterium tuberculosis glycans, do not lead to the evolution of resistance and bypass the need to cross the impermeable mycobacterial cell envelope barrier.

Graphical abstract: Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis

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Article information

DOI
https://doi.org/10.1039/C9OB02222H
Article type
Paper
Submitted
12 Sep 2019
Accepted
16 Oct 2019
First published
29 Oct 2019
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2019,17, 9524-9528

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Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis

C. S. Guy, K. Murray, M. I. Gibson and E. Fullam, Org. Biomol. Chem., 2019, 17, 9524 DOI: 10.1039/C9OB02222H

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