Base-promoted domino radical cyclization of 1,6-enynes

Abstract

A good regioselective, high atom-economical and transition-metal-free method for the synthesis of α-functionalized ether derivatives via the domino radical cyclization of 1,6-enynes is described. A series of α-functionalized ether derivatives could be easily obtained in good yields with wide functional group tolerance by using less toxic and inexpensive Cs₂CO₃ as the base. The control experiment results show that the reaction involves a radical process. This strategy provides a regioselective way toward the formation of dual C–C bonds in one step.