Issue 33, 2019
From the journal:

Organic & Biomolecular Chemistry

Regioselective C–C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium-catalyzed C–H activation†

Ting Tian,‡a   An-Shun Dong,‡a   Dan Chen,a   Xian-Ting Cao*a  and  Guannan Wang*ab  

* Corresponding authors

a The Key Laboratory for Medical Tissue Engineering, College of Medical Engineering, Jining Medical University, P. R. China
E-mail: chemcxt@mail.jnmc.edu.cn

b Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University), Ministry of Education, 389 Xincun Road, 200065 Shanghai, P. R. China

Abstract

A regioselective C–C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium catalysis was developed. This transformation tactically linked the 1,2,4-thiadiazoles and succinimides together, and the novel molecules formed may have potential biological activity.

Graphical abstract: Regioselective C–C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium-catalyzed C–H activation

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Article information

DOI
https://doi.org/10.1039/C9OB01539F
Article type
Communication
Submitted
11 Jul 2019
Accepted
21 Jul 2019
First published
29 Jul 2019

Org. Biomol. Chem., 2019,17, 7664-7668

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Regioselective C–C cross-coupling of 1,2,4-thiadiazoles with maleimides through iridium-catalyzed C–H activation

T. Tian, A. Dong, D. Chen, X. Cao and G. Wang, Org. Biomol. Chem., 2019, 17, 7664 DOI: 10.1039/C9OB01539F

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