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Direct thiocarbamation of imidazoheterocycles via dual C–H sulfurization

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Abstract

A copper-catalyzed DTBP oxidative dual C–H sulfurization has been developed for the direct thiocarbamation of imidazopyridines using a combination of elemental sulfur and formamides as carbamothioyl surrogates. NBS (bromo succinimide) was found to promote the thiocarbamation in good yields. This dual C–H sulfurization strategy enables access to a wide range of carbamothioyl imidazoheterocycles without the use of highly toxic phosgene.

Graphical abstract: Direct thiocarbamation of imidazoheterocycles via dual C–H sulfurization

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Publication details

The article was received on 21 Jun 2019, accepted on 08 Aug 2019 and first published on 08 Aug 2019


Article type: Communication
DOI: 10.1039/C9OB01403A
Org. Biomol. Chem., 2019, Advance Article

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    Direct thiocarbamation of imidazoheterocycles via dual C–H sulfurization

    J. Deng, J. Zhang, M. Li, J. Huang, Z. Lai, X. Tong, Z. Cui and R. Tang, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB01403A

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