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Issue 31, 2019
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Recent advances in the synthesis of oxaspirolactones and their application in the total synthesis of related natural products

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Abstract

Oxaspirolactones are ubiquitous structural motifs found in natural products and synthetic molecules with a diverse biochemical and physicochemical profile, and represent a valuable target in natural product chemistry and medicinal chemistry. Since the 1970s, numerous innovative synthetic methodologies have been reported for these scaffolds in the context of expanding the range of potential building blocks, catalysts, and modes of transformations (racemic or asymmetric protocols). This review focuses on a broad spectrum of approaches toward the synthesis of oxaspirolactones and their potential application in the total synthesis of biologically relevant natural products starting from the first disclosure to the latest report.

Graphical abstract: Recent advances in the synthesis of oxaspirolactones and their application in the total synthesis of related natural products

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Publication details

The article was received on 24 May 2019, accepted on 05 Jul 2019 and first published on 05 Jul 2019


Article type: Review Article
DOI: 10.1039/C9OB01212E
Org. Biomol. Chem., 2019,17, 7270-7292

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    Recent advances in the synthesis of oxaspirolactones and their application in the total synthesis of related natural products

    S. S. Thorat and R. Kontham, Org. Biomol. Chem., 2019, 17, 7270
    DOI: 10.1039/C9OB01212E

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