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Issue 21, 2019
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Chloroform as a CO surrogate: applications and recent developments

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Abstract

The carbonyl moiety is one of the indispensable sub-units in organic synthesis with significant applications in medicinal as well as materials chemistry. Hence the insertion of a carbonyl group via simple and highly efficient routes has been one of the most challenging tasks for organic chemists. Though the direct utilisation of CO gas in carbonylation is the fundamental procedure for the construction of carbonyl compounds, it has certain drawbacks due to its toxic and explosive nature. As a result, the need for cheap and efficient CO surrogates has gained much attention nowadays by which CO gas can be easily generated in situ or ex situ. In this review we discuss the advantages of chloroform as CO surrogate and have surveyed recent carbonylation reactions where chloroform has been used as CO source.

Graphical abstract: Chloroform as a CO surrogate: applications and recent developments

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Publication details

The article was received on 17 Apr 2019, accepted on 24 Apr 2019 and first published on 24 Apr 2019


Article type: Review Article
DOI: 10.1039/C9OB00886A
Org. Biomol. Chem., 2019,17, 5212-5222

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    Chloroform as a CO surrogate: applications and recent developments

    K. Mondal, P. Halder, G. Gopalan, P. Sasikumar, K. V. Radhakrishnan and P. Das, Org. Biomol. Chem., 2019, 17, 5212
    DOI: 10.1039/C9OB00886A

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