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Issue 19, 2019
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Total synthesis of (±)-epi-stemodan-13α,17-diol

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Stemodan-13α,17-diol is a natural stemodane-type diterpenoid isolated from Stemodia chilensis. Herein we report the total synthesis of its epimer, stemodan-13β,17-diol, by applying titanium-mediated polyene cyclization and iron-catalyzed [5 + 2] cycloaddition as the key transformations to expeditiously install the molecular scaffold.

Graphical abstract: Total synthesis of (±)-epi-stemodan-13α,17-diol

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The article was received on 21 Mar 2019, accepted on 17 Apr 2019 and first published on 18 Apr 2019

Article type: Communication
DOI: 10.1039/C9OB00661C
Org. Biomol. Chem., 2019,17, 4711-4714

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    Total synthesis of (±)-epi-stemodan-13α,17-diol

    S. Chen, T. Chen, G. Liu, X. Wang, G. Zhu, Y. Liu, S. Fu and B. Liu, Org. Biomol. Chem., 2019, 17, 4711
    DOI: 10.1039/C9OB00661C

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