Jump to main content
Jump to site search

Issue 16, 2019
Previous Article Next Article

Ruthenium(II)/acetate catalyzed intermolecular dehydrogenative ortho C–H silylation of 2-aryl N-containing heterocycles

Author affiliations

Abstract

The first application of a RuHCl(CO)(PPh3)3–OAc catalytic system on the selective intermolecular mono C–H silylation of 2-aryl N-heterocycles using HSiEt3 as the silylating reagent has been described. This protocol features good functional group tolerance and high regioselectivity, and has potential for gram scale-up, which provides a convenient and practical pathway for the synthesis of versatile organosilane compounds. This catalytic system can also be applied to the silylation of challenging sp3 C–H bonds.

Graphical abstract: Ruthenium(ii)/acetate catalyzed intermolecular dehydrogenative ortho C–H silylation of 2-aryl N-containing heterocycles

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Mar 2019, accepted on 29 Mar 2019 and first published on 30 Mar 2019


Article type: Paper
DOI: 10.1039/C9OB00609E
Citation: Org. Biomol. Chem., 2019,17, 4115-4120

  •   Request permissions

    Ruthenium(II)/acetate catalyzed intermolecular dehydrogenative ortho C–H silylation of 2-aryl N-containing heterocycles

    S. Liu, Q. Lin, C. Liao, J. Chen, K. Zhang, Q. Liu and B. Li, Org. Biomol. Chem., 2019, 17, 4115
    DOI: 10.1039/C9OB00609E

Search articles by author

Spotlight

Advertisements