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Oxidative Sulfonamidomethylation of Imidazopyridines Utilizing Methanol as the Main C1 Source

Abstract

An efficient one pot, three component syntheses of C3 sulfonamidomethylated imidazopyridines has been disclosed under metal-free conditions, which utilized commercial available and renewable reagent methanol as the main methylene source. A wide range of substituted imidazopyridines and sulfamides/amines were well tolerated to afford the corresponding products in up to 92% yield. In the isotopic labelling experiment, it was found that a minority of methylene source was also originated from DTBP. Moreover, the radical scavenger reactions were conducted, suggesting that a free-radical mechanism is probably not involved. The current methodology was featured with several advantages, including broad substrate scope, good functional group tolerance and high reaction efficiency.

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Publication details

The article was received on 13 Mar 2019, accepted on 12 Apr 2019 and first published on 15 Apr 2019


Article type: Paper
DOI: 10.1039/C9OB00596J
Citation: Org. Biomol. Chem., 2019, Accepted Manuscript

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    Oxidative Sulfonamidomethylation of Imidazopyridines Utilizing Methanol as the Main C1 Source

    X. Zhao, E. Huang, Y. Zhu, J. Li, B. Song, X. Zhu and X. Hao, Org. Biomol. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9OB00596J

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