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Issue 22, 2019
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Design of S–S bond containing maleimide-conjugated closo-dodecaborate (SSMID): identification of unique modification sites on albumin and investigation of intracellular uptake

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Abstract

An S–S bond containing maleimide-conjugated closo-dodecaborate (SSMID) was synthesised for identification of albumin binding sites. Three Lys residues, Lys221, Lys413 and Lys431, were identified as SSMID modification sites in addition to Cys34 in bovin serum albumin (BSA). Fluorescent-labelled MID-BSA was found to be accumulated in the cytosol of HeLa cells.

Graphical abstract: Design of S–S bond containing maleimide-conjugated closo-dodecaborate (SSMID): identification of unique modification sites on albumin and investigation of intracellular uptake

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Publication details

The article was received on 12 Mar 2019, accepted on 01 Apr 2019 and first published on 03 Apr 2019


Article type: Communication
DOI: 10.1039/C9OB00584F
Org. Biomol. Chem., 2019,17, 5496-5499

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    Design of S–S bond containing maleimide-conjugated closo-dodecaborate (SSMID): identification of unique modification sites on albumin and investigation of intracellular uptake

    S. Ishii, S. Sato, H. Asami, T. Hasegawa, J. Kohno and H. Nakamura, Org. Biomol. Chem., 2019, 17, 5496
    DOI: 10.1039/C9OB00584F

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