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Issue 22, 2019
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Design of S–S bond containing maleimide-conjugated closo-dodecaborate (SSMID): identification of unique modification sites on albumin and investigation of intracellular uptake

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Abstract

An S–S bond containing maleimide-conjugated closo-dodecaborate (SSMID) was synthesised for identification of albumin binding sites. Three Lys residues, Lys221, Lys413 and Lys431, were identified as SSMID modification sites in addition to Cys34 in bovin serum albumin (BSA). Fluorescent-labelled MID-BSA was found to be accumulated in the cytosol of HeLa cells.

Graphical abstract: Design of S–S bond containing maleimide-conjugated closo-dodecaborate (SSMID): identification of unique modification sites on albumin and investigation of intracellular uptake

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Supplementary files

Article information


Submitted
12 Mar 2019
Accepted
01 Apr 2019
First published
03 Apr 2019

Org. Biomol. Chem., 2019,17, 5496-5499
Article type
Communication

Design of S–S bond containing maleimide-conjugated closo-dodecaborate (SSMID): identification of unique modification sites on albumin and investigation of intracellular uptake

S. Ishii, S. Sato, H. Asami, T. Hasegawa, J. Kohno and H. Nakamura, Org. Biomol. Chem., 2019, 17, 5496
DOI: 10.1039/C9OB00584F

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