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Transmembrane H+/Cl cotransport activity of bis(amido)imidazole receptors

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Abstract

A series of sickle-shaped bis(amido) imidazoles are synthesized for their ion transport studies. Proton–anion binding by the neutral and protonated form of receptors assessed by 1H-NMR titration experiments confirmed better chloride binding by the protonated form of a receptor compared to its neutral form. The transport experiments across unimolecular vesicles (by HPTS and lucigenin assays) confirmed the H+/Cl symport process under the applied pH gradient conditions. The transporter also allows anion antiport as evident from the studies under symmetrical pH conditions. The ionophoric activity by the mobile carrier mechanism is proved by the U-tube experiment.

Graphical abstract: Transmembrane H+/Cl− cotransport activity of bis(amido)imidazole receptors

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Publication details

The article was received on 08 Mar 2019, accepted on 01 Apr 2019 and first published on 01 Apr 2019


Article type: Paper
DOI: 10.1039/C9OB00554D
Citation: Org. Biomol. Chem., 2019, Advance Article

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    Transmembrane H+/Cl cotransport activity of bis(amido)imidazole receptors

    S. V. Shinde and P. Talukdar, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB00554D

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