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Issue 22, 2019
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Strategies towards the synthesis of anti-tuberculosis drugs

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Abstract

Antituberculosis drugs have captured the attention of the scientific community due to the emergence of drug resistance. Hence, the development of new analogs and new drugs which can treat drug-resistant tuberculosis is required. In this report, we reviewed the strategies towards the synthesis of antituberculosis drugs. These strategies include semisynthetic approaches, resolution based strategies, microbial transformations, solid phase synthesis, and asymmetric synthesis. As stereochemistry is an important hallmark of many drugs, the strategies based on asymmetric synthesis are described in detail. The emphasis on semisynthetic approaches is given for aminoglycoside antibiotics.

Graphical abstract: Strategies towards the synthesis of anti-tuberculosis drugs

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Article information


Submitted
08 Mar 2019
Accepted
01 May 2019
First published
01 May 2019

Org. Biomol. Chem., 2019,17, 5428-5459
Article type
Review Article

Strategies towards the synthesis of anti-tuberculosis drugs

H. B. Rode, D. M. Lade, R. Grée, P. S. Mainkar and S. Chandrasekhar, Org. Biomol. Chem., 2019, 17, 5428
DOI: 10.1039/C9OB00817A

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