Megumi Okada, Kazuma Kaneko, Masahiro Yamanaka and Seiji Shirakawa
Org. Biomol. Chem., 2019,17, 3747-3751
DOI:
10.1039/C9OB00417C,
Communication
An efficient enantioselective synthesis of 3,3-disubstituted phthalides possessing a chiral quaternary carbon center was achieved via catalytic asymmetric bromolactonization that utilized BINOL-derived bifunctional sulfide catalysts. Transformations of the bromo group in optically active phthalide products were also performed to demonstrate the utility of this novel synthetic protocol.
