One-pot Synthesis of Ln3+-doped Porous BiF3@PAA Nanospheres for Temperature Sensing and pH-Responsive Drug Delivery guided by CT Imaging
Design and synthesis of responsive inorganic nanocapsules have attracted intensive research interest in cancer treatment. Combinational of non-invasive diagnosis and chemotherapy into a single theranostic nanoplatform is prospective in biomedical field. In this work, polyacrylic acid (PAA)-functionalized porous BiF3:Yb,Er nanocarrier was constructed by a straightforward one-pot solvothermal strategy. Compared with undoped BiF3 sub-microspheres, the lanthanide ions (Ln3+) doping endows the BiF3 material with decreased sizes and increased BET specific surface area or pore volume, which make it suitable as drug carriers. It was found that the synthesized nanomaterial could effectively relieve the side effects of doxorubicin (DOX) and exhibited pH-dependent DOX loading and release manner. Satisfied biocompatibility and efficient tumor inhibition were emphasized by a series of in vitro/in vivo experiments. In addition, the synthesized nanomaterial exhibits favorable CT contrast efficacy due to excellent X-ray attenuation coefficient of Bi. Moreover, characteristic upconversion luminescence and temperature sensing in a wide temperature range were realized over the synthesized BiF3:Yb,Er sample. Therefore, the carboxyl-functionalized BiF3:Yb,Er can be expected to be ideal candidates in fabricating temperature sensing or multifunctional theranostic nanoplatforms.