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A spherical nucleic acid-based two-photon nanoprobe for RNase H activity assay in living cells and tissues

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Abstract

We report here a two-photon nanoprobe for the detection of RNase H activity in living cells and ex vivo tissues by combining a two-photon dye with a spherical nucleic acid (SNA) featuring a DNA/RNA duplex corona and a gold nanoparticle core.

Graphical abstract: A spherical nucleic acid-based two-photon nanoprobe for RNase H activity assay in living cells and tissues

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Publication details

The article was received on 28 Jan 2019, accepted on 04 Apr 2019 and first published on 08 Apr 2019


Article type: Communication
DOI: 10.1039/C9NR00880B
Citation: Nanoscale, 2019, Advance Article

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    A spherical nucleic acid-based two-photon nanoprobe for RNase H activity assay in living cells and tissues

    N. Wang, L. Song, H. Xing, K. Zhang, R. Yang and J. Li, Nanoscale, 2019, Advance Article , DOI: 10.1039/C9NR00880B

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