Jump to main content
Jump to site search


Heterologous expression of bacterial natural product biosynthetic pathways

Author affiliations

Abstract

Covering: 2013 to June 2018

Heterologous expression of natural product biosynthetic pathways is of increasing interest in microbial biotechnology, drug discovery and optimization. It empowers not only the robust production of valuable biomolecules in more amenable heterologous hosts but also permits the generation of novel analogs through biosynthetic engineering. This strategy also facilitates the discovery of novel bioactive compounds following the functional expression of cryptic biosynthetic gene clusters (BGCs) from fastidious original producers or metagenomic DNA in surrogate hosts, thus facilitating genome mining in the post-genomic era. This review discusses recent advances and trends pertaining to the heterologous production of bacterial natural products, with an emphasis on new techniques, heterologous hosts, and novel chemistry since 2013.

Graphical abstract: Heterologous expression of bacterial natural product biosynthetic pathways

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Nov 2018 and first published on 08 Jan 2019


Article type: Review Article
DOI: 10.1039/C8NP00091C
Citation: Nat. Prod. Rep., 2019, Advance Article
  •   Request permissions

    Heterologous expression of bacterial natural product biosynthetic pathways

    L. Huo, J. J. Hug, C. Fu, X. Bian, Y. Zhang and R. Müller, Nat. Prod. Rep., 2019, Advance Article , DOI: 10.1039/C8NP00091C

Search articles by author

Spotlight

Advertisements