Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.

Issue 10, 2019
Previous Article Next Article

The intriguing chemistry and biology of soraphens

Author affiliations


Covering: up to the end of 2018

Soraphens are a class of polyketide natural products discovered from the myxobacterial strain Sorangium cellulosum. The review is intended to provide an overview on the biosynthesis, chemistry and biological properties of soraphens, that represent a prime example to showcase the value of natural products as tools to decipher cell biology, but also to open novel therapeutic options. The prototype soraphen A is an inhibitor of acetyl coenzyme A carboxylase (ACC1/2), an enzyme that converts acetyl-CoA to malonyl-CoA and thereby controls essential cellular metabolic processes like lipogenesis and fatty acid oxidation. Soraphens illustrate how the inhibition of a single target (ACC1/2) may be explored to treat various pathological conditions: initially developed as a fungicide, efforts in the past decade were directed towards human diseases, including diabetes/obesity, cancer, hepatitis C, HIV, and autoimmune disease – and led to a synthetic molecule, discovered by virtual screening of the allosteric binding site of soraphen in ACC, that is currently in phase 2 clinical trials. We will summarize how structural analogs of soraphen A have been generated through extensive isolation efforts, genetic engineering of the biosynthetic gene cluster, semisynthesis as well as partial and total synthesis.

Graphical abstract: The intriguing chemistry and biology of soraphens

Back to tab navigation

Article information

01 Feb 2019
First published
05 Apr 2019

Nat. Prod. Rep., 2019,36, 1394-1411
Article type
Review Article

The intriguing chemistry and biology of soraphens

A. Naini, F. Sasse and M. Brönstrup, Nat. Prod. Rep., 2019, 36, 1394
DOI: 10.1039/C9NP00008A

Social activity

Search articles by author