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Recent advances in the synthesis of gem-dimethylcyclobutane natural products

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Abstract

Covering: January 2000 to July 2018

gem-Dimethylcyclobutanes are a common motif found in a multitude of natural products, and thus these structures have captivated synthetic chemists for years. However, until the turn of the century, most synthetic efforts relied upon the use of widely available terpenes, such as pinene or caryophyllene, that already contain the gem-dimethylcyclobutane motif. This approach limits the scope of molecules that can be accessed readily. This review highlights recent syntheses in which the gem-dimethylcyclobutane is assembled via de novo approaches. An outlook on the future of this research area is also provided.

Graphical abstract: Recent advances in the synthesis of gem-dimethylcyclobutane natural products

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Publication details

The article was received on 01 Oct 2018 and first published on 11 Mar 2019


Article type: Highlight
DOI: 10.1039/C8NP00083B
Nat. Prod. Rep., 2019, Advance Article

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    Recent advances in the synthesis of gem-dimethylcyclobutane natural products

    Erin N. Hancock, J. M. Wiest and M. K. Brown, Nat. Prod. Rep., 2019, Advance Article , DOI: 10.1039/C8NP00083B

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