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Total Synthesis of (–)-Aplaminal by Buchwald–Hartwig Cross-Coupling of an Aminal

Abstract

The concise total synthesis of a unique alkaloid, aplaminal, has been accomplished. The synthetic feature is the Buchwald–Hartwig cross-coupling between a novel triazabicyclo[3.2.1]octane core and an aromatic bromide. The practicality of our approach provides for aplaminal analogs and preliminary structure–cytotoxicity relationships of aromatic moiety were acheived.

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Publication details

The article was received on 17 Sep 2019, accepted on 05 Nov 2019 and first published on 06 Nov 2019


Article type: Letter
DOI: 10.1039/C9NJ04743C
New J. Chem., 2019, Accepted Manuscript

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    Total Synthesis of (–)-Aplaminal by Buchwald–Hartwig Cross-Coupling of an Aminal

    T. Ohyoshi, K. Akemoto, A. Taniguchi, T. Ishihara and H. Kigoshi, New J. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9NJ04743C

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