Jump to main content
Jump to site search


Total synthesis of (−)-aplaminal by Buchwald–Hartwig cross-coupling of an aminal

Author affiliations

Abstract

The concise total synthesis of an unusual alkaloid, aplaminal, has been accomplished. The synthetic feature is the Buchwald–Hartwig cross-coupling between a novel triazabicyclo[3.2.1]octane core and an aromatic bromide. The practicality of our approach provides aplaminal analogs and preliminary structure–cytotoxicity relationships of an aromatic moiety were achieved.

Graphical abstract: Total synthesis of (−)-aplaminal by Buchwald–Hartwig cross-coupling of an aminal

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Sep 2019, accepted on 05 Nov 2019 and first published on 06 Nov 2019


Article type: Letter
DOI: 10.1039/C9NJ04743C
New J. Chem., 2019, Advance Article

  •   Request permissions

    Total synthesis of (−)-aplaminal by Buchwald–Hartwig cross-coupling of an aminal

    T. Ohyoshi, K. Akemoto, A. Taniguchi, T. Ishihara and H. Kigoshi, New J. Chem., 2019, Advance Article , DOI: 10.1039/C9NJ04743C

Search articles by author

Spotlight

Advertisements