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A PET-based lysosome-targeted turn-on fluorescent probe for the detection of H2S and its bioimaging application in living cells and zebrafish

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Abstract

Based on a coumarin platform modified with morpholine and 2,4-dinitrobenzosulfonyl groups, a lysosome-targeted turn-on fluorescent probe CMDN has been rationally designed and synthesized to detect H2S via the photoinduced electron transfer (PET) mechanism. The probe CMDN has a rapid response to analytes and is capable of detecting H2S in aqueous and living biological systems through a turn-on fluorescence signal. Furthermore, with a specific location group, CMDN can be well localized in cell lysosomes with a high colocalization coefficient, visualize exogenous and endogenous H2S in cells and detect H2S in zebrafish.

Graphical abstract: A PET-based lysosome-targeted turn-on fluorescent probe for the detection of H2S and its bioimaging application in living cells and zebrafish

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Publication details

The article was received on 25 Jul 2019, accepted on 24 Sep 2019 and first published on 08 Oct 2019


Article type: Letter
DOI: 10.1039/C9NJ03862K
New J. Chem., 2019, Advance Article

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    A PET-based lysosome-targeted turn-on fluorescent probe for the detection of H2S and its bioimaging application in living cells and zebrafish

    X. Jing, F. Yu and W. Lin, New J. Chem., 2019, Advance Article , DOI: 10.1039/C9NJ03862K

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