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Metal-free thioesterification of amides generating acyl thioesters

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Abstract

A base-initiated thioesterification of amides with various thiols is reported. This reaction can take place efficiently under metal-free and air-atmospheric conditions, and provides a facile and practically useful approach to the synthesis of valuable acyl thioesters.

Graphical abstract: Metal-free thioesterification of amides generating acyl thioesters

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Publication details

The article was received on 05 Apr 2019, accepted on 15 May 2019 and first published on 16 May 2019


Article type: Paper
DOI: 10.1039/C9NJ01748H
New J. Chem., 2019, Advance Article

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    Metal-free thioesterification of amides generating acyl thioesters

    Q. Wang, L. Liu, J. Dong, Z. Tian and T. Chen, New J. Chem., 2019, Advance Article , DOI: 10.1039/C9NJ01748H

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