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Folate targeting and bovine serum albumin gated mesoporous silica nanoparticles as a redox-responsive carrier for epirubicin release

Abstract

A distinctive nanomaterial-based mesoporous silica nanoparticle (MSN) successively coupled with bovine serum albumin (BSA) and folic acid (FA) has been engineered for targeting epirubicin (EPI) release. BSA molecule as a “gatekeeper” prevents the untimely drug leakage until the BSA coating layer is biodegraded as a response to GSH. FA promotes the specific intracellular delivery of drug to high folate receptor (FR) expression cancer cells for ameliorating the efficacy of chemotherapy. In vitro drug release profiles show that drug carrier can avoid premature release under physiological conditions and redox responsive EPI release is significantly accelerating from EPI/MSN-FA by easily biodegradable in the presence of GSH due to the cleavage of the intramolecular disulfide bond, realizing the “redox triggered release” of drug in the simulation targeted tissues microenvironment. Folate mediated cellular uptake measured by confocal laser scanning microscope (CLSM) is tracing that the hybrid nanoparticles more likely pitch into FR-positive (FR+) HepG2 cells than FR-negative (FR-) PC-12 cells. The toxicity experiment also demonstrates the negligible toxicity of MSN-FA and increasingly antitumor suppression of EPI/MSN-FA with ascending dosage. The results show the strategy of combining mesoporous silica with the stimuli-responsive biodegradability of protein molecules will offer new potential directions in “on-demand” drug release for pinpoint chemotherapy in cancer treatment.

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Supplementary files

Publication details

The article was received on 29 Oct 2018, accepted on 07 Jan 2019 and first published on 08 Jan 2019


Article type: Paper
DOI: 10.1039/C8NJ05476B
Citation: New J. Chem., 2019, Accepted Manuscript
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    Folate targeting and bovine serum albumin gated mesoporous silica nanoparticles as a redox-responsive carrier for epirubicin release

    Y. Zhang, Y. Xing, M. Xian, S. Shuang and C. Dong, New J. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C8NJ05476B

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