Pharmacokinetic/pharmacodynamic modelling of effective components of Fangji Huangqi Tang for its treatment of nephrotic syndrome

Abstract

This study was designed to evaluate the potential effective components of Fangji Huangqi Tang for the treatment of nephrotic syndrome based on a pharmacokinetic/pharmacodynamic model. To quantify the relationships between the pharmacokinetics and pharmacodynamics of fangchinoline and tetrandrine, the pharmacokinetic/pharmacodynamic model was set up by combining pharmacokinetic parameters and the effective indexes in rats. Compared with a model group, the effective indexes including serum urea nitrogen, cysteine protease inhibitors C, total cholesterol and triglycerides in the FHT group became significantly lower with a dosing time extension. The pharmacokinetic/pharmacodynamic modeling results showed that there were good linear relationships between the areas under the concentration-time curves and these effective indexes. Finally, fangchinoline and tetrandrine were proved to be the main effective chemical materials of FHT to cure nephrotic syndrome in rats.