Bacteria employ a number of mechanisms to resist the effects of antibiotics, including the formation of biofilms. We explored the anti-biofilm capabilities of a library of compounds based upon a 2-aminoquinazoline (2-AQ) scaffold against Mycobacterium smegmatis. This study resulted in the identification of 2-AQ derivatives with biofilm inhibition activity against M. smegmatis.
K. E. Cox and C. Melander, Med. Chem. Commun., 2019, 10, 1177 DOI: 10.1039/C9MD00156E
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