Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 2, 2019
Previous Article Next Article

Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites

Author affiliations

Abstract

Novel primaquine–cell penetrating peptide conjugates were synthesised and tested in vitro against liver stage Plasmodium berghei parasites. Generally, the conjugates were more active than the parent peptides and, in some cases, than the parent drug. These are unprecedented findings that may open a new route towards antimalarial drug rescuing.

Graphical abstract: Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites

Back to tab navigation

Publication details

The article was received on 05 Sep 2018, accepted on 13 Nov 2018 and first published on 16 Nov 2018


Article type: Research Article
DOI: 10.1039/C8MD00447A
Citation: Med. Chem. Commun., 2019,10, 221-226

  •   Request permissions

    Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites

    L. Aguiar, M. Machado, M. Sanches-Vaz, M. Prudêncio, N. Vale and P. Gomes, Med. Chem. Commun., 2019, 10, 221
    DOI: 10.1039/C8MD00447A

Search articles by author

Spotlight

Advertisements