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Electrochemical Oxidative Annulation from Amines and Aldehydes or Ketones to Synthesize Polysubstituted Pyrroles

Abstract

A general and practical protocol to synthesize polysubstituted pyrroles has been established by electrooxidative annulation from amines and aldehydes or ketones. In undivided cell, arylacetaldehydes and primary amines can participate in this transformation smoothly to furnish β-substituded pyrrols under external oxidant-free conditions. Tetrasubstituted pyrroles could be obtained efficiently by using imines as substrates. In addition, this reaction can be extended to gram levels; the final products can also proceed later stage functionalization.

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Publication details

The article was received on 24 Jun 2019, accepted on 14 Aug 2019 and first published on 14 Aug 2019


Article type: Communication
DOI: 10.1039/C9GC02118C
Green Chem., 2019, Accepted Manuscript

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    Electrochemical Oxidative Annulation from Amines and Aldehydes or Ketones to Synthesize Polysubstituted Pyrroles

    X. Gao, P. Wang, Q. Wang, J. Chen and A. Lei, Green Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9GC02118C

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