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Effects of a Ganoderma atrum polysaccharide against pancreatic damage in streptozotocin-induced diabetic mice

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Abstract

This study aimed at exploring the role of a Ganoderma atrum polysaccharide (PSG-1) in pancreatic damage in streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) mice. The results suggested that blood glucose was significantly increased in the STZ group in comparison with the control group. After 4 weeks of treatment with PSG-1 or metformin (MET), blood glucose levels in the PSG-1 and MET groups were apparently lower than in the STZ group, indicating that PSG-1 triggered hypoglycemic effects in vivo. Moreover, experiments demonstrated that PSG-1 markedly decreased apoptosis of islet cells by inhibiting the mitochondrial apoptotic pathway and activating the PI3K/Akt survival pathway. PSG-1 also exerted anti-inflammatory effects, as evidenced by the dramatically decreased levels of IL-1β, TNF-α and INF-γ and restraint of the TLR4-dependent NF-κB signal pathway. Meanwhile, PSG-1 maintained homeostasis of redox systems by increasing the activities of anti-oxidant enzymes and decreasing the amount of malondialdehyde in the pancreas. Together, these data provide evidence that PSG-1 can be employed as an alternative dietary supplement to ameliorate T1DM.

Graphical abstract: Effects of a Ganoderma atrum polysaccharide against pancreatic damage in streptozotocin-induced diabetic mice

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Publication details

The article was received on 28 Aug 2019, accepted on 26 Sep 2019 and first published on 27 Sep 2019


Article type: Paper
DOI: 10.1039/C9FO01990A
Food Funct., 2019, Advance Article

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    Effects of a Ganoderma atrum polysaccharide against pancreatic damage in streptozotocin-induced diabetic mice

    L. Li, R. Li, Y. Song, W. Wu, S. Yin, W. Fu, R. Wu and W. Li, Food Funct., 2019, Advance Article , DOI: 10.1039/C9FO01990A

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