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Bilberry anthocyanin improve the serum cholesterol profile in aging perimenopausal rats via the estrogen receptor signaling pathway

Abstract

With aging, there is an increasing risk for women to develop perimenopause syndrome, which is harmful to women's physical and mental health. The present study investigated the health benefits of bilberry anthocyanin (BA) on aging perimenopausal Sprague-Dawley rats. Rats that entered into perimenopause through natural aging were treated for 8 weeks with BA, and received either a low dose (LD, 35 mg/kg of bodyweight), medium dose (MD, 70 mg/kg of bodyweight), or high dose (HD, 140 mg/kg of bodyweight). The experimental results suggested that all three dosages of BA, especially the high dose, significantly reduced the serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) levels. In addition, BA supplementation markedly reduced the serum malondialdehyde (MDA), effectively increased the activity of hepatic total superoxide dismutase (T-SOD), significantly raised the high density lipoprotein cholesterol (HDL-C), increased the number of estrogen receptors, and effectively up-regulated the expression levels of G protein-coupled receptor 30 (GPR30), protein kinase B (AKT), and extracellular regulated protein kinase 2 (ERK2). In summary, BA has a great effect on improving the serum cholesterol in natural aging perimenopausal rats via the estrogen receptor signaling pathway, and it may be used as a dietary supplement for perimenopause women to decrease the risk of cardiovascular disease.

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Supplementary files

Publication details

The article was received on 27 Mar 2019, accepted on 10 May 2019 and first published on 13 May 2019


Article type: Paper
DOI: 10.1039/C9FO00639G
Food Funct., 2019, Accepted Manuscript

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    Bilberry anthocyanin improve the serum cholesterol profile in aging perimenopausal rats via the estrogen receptor signaling pathway

    N. Li, J. Hao, J. Li, M. Zhang, J. Geng, J. Yin, T. Wu and X. Lu, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C9FO00639G

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