Jump to main content
Jump to site search


Beneficial effects of purple yam (Dioscorea alata L.) resistant starch on hyperlipidemia in high-fat-fed hamsters

Abstract

This study investigated the interventional effect of resistant starch (RS) from purple yam (Dioscorea alata L.) on regulating lipid metabolism and gut microbiota in hyperlipidemic hamsters. Compared to low level of RS (LR) treatment, high dosage of RS (HR) administration in hamsters showed more efficient in controlling body weight and adipose tissue mass, together with an increased high-density lipoprotein cholesterol (HDL-C) concentration and decreased triglyceride (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) concentrations. Fat accumulation in the liver was reduced by RS, and the injury of high-fat diet on the histomorphology of cecum and colon was repaired. Furthermore, HR altered the gut community composition by increasing the relative abundances of Bifidobacteria, Lactobacillus, Coprococcus and Allobaculum, while decreasing Parabacteroides and Dorea. Probiotics, such as Bifidobacteria and Lactobacillus, dramatically increased and highly correlated with blood lipid levels. These results suggested that usage of RS from purple yam could ameliorate lipid metabolism in association with gut microbiota modulation, which could provide references for further medication.

Back to tab navigation

Publication details

The article was received on 18 Dec 2018, accepted on 28 Feb 2019 and first published on 21 Mar 2019


Article type: Paper
DOI: 10.1039/C8FO02502A
Citation: Food Funct., 2019, Accepted Manuscript

  •   Request permissions

    Beneficial effects of purple yam (Dioscorea alata L.) resistant starch on hyperlipidemia in high-fat-fed hamsters

    T. Li, H. Teng, F. An, Q. Huang, L. Chen and H. Song, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C8FO02502A

Search articles by author

Spotlight

Advertisements