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DHA-PC protects kidney against cisplatin-induced toxicity and its underlying mechanisms in mice

Abstract

Cisplatin is an effective chemotherapeutic agent to treat various cancers; however, it was usually complicated by nephrotoxic side effects, which limits its application in clinical. Interestingly, DHA supplementation also exhibit anticancer activity without any side effects. It is noted that DHA-PC has been applied in the treatment of kidney diseases. Our aim in the current study was to investigate whether DHA-PC treatment could alleviate nephrotoxicity for cancer patients using a model of cisplatin-induced Balb/c mice. Results showed that DHA-PC could significantly prolong the survival time, while traditional DHA had no remarkable changes. In addition, short supplements of DHA-PC alleviated cisplatin-induced kidney dysfunction, such as blood urea nitrogen and creatinine. The protective effect of DHA-PC against cisplatin-induced nephrotoxicity might be attributed to the inhibition of mitochondrial dysfunction, oxidative stress and inactivate mitogen-activated protein kinase signaling pathway, suggesting that DHA-PC might be acted as dietary supplements or functional foods against cisplatin-induced nephrotoxicity.

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Publication details

The article was received on 03 Dec 2018, accepted on 30 Jan 2019 and first published on 08 Feb 2019


Article type: Paper
DOI: 10.1039/C8FO02386G
Citation: Food Funct., 2019, Accepted Manuscript

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    DHA-PC protects kidney against cisplatin-induced toxicity and its underlying mechanisms in mice

    H. Shi, C. Wang, Y. Guo, C. Xue, T. Zhang and Y. Wang, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C8FO02386G

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