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Free volume and dynamics in a lipid bilayer

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Abstract

The lateral diffusion of lipids and of small molecules inside a membrane is strictly related to the arrangement of acyl chains and to their mobility. In this study, we use FTIR and time resolved 2D-IR spectroscopic techniques to characterize the structure and dynamics of the hydrophobic region of palmitoyl-oleylphosphatidylcholine/cholesterol vesicles dispersed in water/dimethylsulfoxide solutions. By means of a non-polar probe, hexacarbonyl tungsten, we monitor the distribution of free volumes inside the bilayer and the conformational dynamics of hydrophobic tails in relation to the different compositions of the membrane or the different compositions of the solvent. Despite the important structural changes induced by the presence of DMSO in the solvating medium, the picosecond dynamics of the membrane is preserved under the different conditions.

Graphical abstract: Free volume and dynamics in a lipid bilayer

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Publication details

The article was received on 19 Jun 2019, accepted on 29 Sep 2019 and first published on 30 Sep 2019


Article type: Paper
DOI: 10.1039/C9CP03451J
Phys. Chem. Chem. Phys., 2019, Advance Article

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    Free volume and dynamics in a lipid bilayer

    B. Gironi, A. Lapini, E. Ragnoni, C. Calvagna, M. Paolantoni, A. Morresi and P. Sassi, Phys. Chem. Chem. Phys., 2019, Advance Article , DOI: 10.1039/C9CP03451J

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