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Characterization of drug–drug salt forms of metformin and aspirin with improved physicochemical properties

Abstract

A drug–drug salt was prepared consisting of metformin and aspirin with two crystalline phases characterized. A hydrophilic surface induced recrystallization mechanism was supposed for the transition from its anhydrate to hemihydrate. The modulated solubility property of the dual drug would help to overcome the associated gastrointestinal side effects to some extent.

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Publication details

The article was received on 14 Mar 2019, accepted on 08 May 2019 and first published on 10 May 2019


Article type: Communication
DOI: 10.1039/C9CE00377K
CrystEngComm, 2019, Accepted Manuscript

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    Characterization of drug–drug salt forms of metformin and aspirin with improved physicochemical properties

    W. Zhou, H. Zhao, H. Chen, Z. Zhang and D. Chen, CrystEngComm, 2019, Accepted Manuscript , DOI: 10.1039/C9CE00377K

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