Self-suppression from metabolin with a precursor in pathology crystallization of gout

Abstract

Hyperuricemia is typically defined as occurring above the saturation point of monosodium urate monohydrate (MSUM), which occurs at serum urate levels >6.8 mg dL⁻¹. Xanthine(X), a precursor molecule of uric acid, was found to inhibit the growth of MSUM crystals through incorporating into the surface of bulk crystal of MSUM. This approach can provide us with a new perspective that will help our understanding of the heterogeneity of gout in hyperuricemics and the processes of crystal formation and growth of MSUM.