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Issue 25, 2019
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Characterization of drug–drug salt forms of metformin and aspirin with improved physicochemical properties

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Abstract

A drug–drug salt was prepared consisting of metformin and aspirin with two crystalline phases characterized. A hydrophilic surface induced recrystallization mechanism was supposed for the transition from anhydrate to hemihydrate. The modulated solubility properties of the dual drug would help to overcome the associated gastrointestinal side effects to some extent.

Graphical abstract: Characterization of drug–drug salt forms of metformin and aspirin with improved physicochemical properties

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Publication details

The article was received on 14 Mar 2019, accepted on 08 May 2019 and first published on 10 May 2019


Article type: Communication
DOI: 10.1039/C9CE00377K
CrystEngComm, 2019,21, 3770-3773

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    Characterization of drug–drug salt forms of metformin and aspirin with improved physicochemical properties

    W. Zhou, H. Zhao, H. Chen, Z. Zhang and D. Chen, CrystEngComm, 2019, 21, 3770
    DOI: 10.1039/C9CE00377K

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