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Issue 13, 2019
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Co-crystallization and polymorphic behaviour of 5-fluorouracil

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Abstract

Syntheses and single-crystal characterization of two co-crystalline 5-fluorouracil compounds with nontoxic co-formers of the GRAS list, succinic acid and adipic acid, are presented. Furthermore, the target-oriented synthon approach from methanol or ethanol (technical grade) to polymorphic form II, which is hitherto only accessible from dry nitromethane, is described.

Graphical abstract: Co-crystallization and polymorphic behaviour of 5-fluorouracil

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Article information


Submitted
05 Oct 2018
Accepted
12 Nov 2018
First published
13 Nov 2018

CrystEngComm, 2019,21, 2130-2134
Article type
Paper

Co-crystallization and polymorphic behaviour of 5-fluorouracil

D. D. Enkelmann, J. Handelmann, C. Schauerte and K. Merz, CrystEngComm, 2019, 21, 2130
DOI: 10.1039/C8CE01692E

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